Venerable actress and ten-time César Award nominee, Miou-Miou (Memoirs of a French Whore and This Sweet Sickness) stars as family matriarch, Nona, who runs a planned parenthood clinic in Paris. Nona is fiercely independent and does not feel the need to be forthcoming about her personal life, which now includes a pregnancy at the age of seventy. Nona is irritated at the fuss her grown triplet daughters, doctor, and lover André make about her pregnancy. As she comes to terms with the unwanted attention by her family and others, her role as mother is ever-present and gentle towards the family she already has.

Valérie Donzelli acts in and makes her television directorial debut in Nona and Her Daughters. George is the only daughter who never moved out of her childhood bedroom. She is forever looking for a thesis topic and re-focuses her academic energies on finding out the father of her soon-to-be born sibling. George enlists the help of Antoine, a genetics researcher, to solve the paternity mystery. Her partnership with Antoine is mismatched in many ways leading to inevitable consequences.

Recently known for the role of Juliette Pelegrini in Lupin, Clotilde Hesme plays the career-driven sexologist Gabrielle (Gaby). As busy as Gaby is – there are books to promote and clients to see – Gaby’s confidence falters as she is confronted with her secret past while also conflicted about her attraction to Paou, her mom’s male midwife who moves into the cramped apartment to monitor Nona. Despite Gaby’s independence, she needs the support of her family the most.

Virginie Ledoyen has been acting since age 2, but is known outside of France for her role in The Beach (2000) with Leonardo DiCaprio. Emmanuelle (Manu) has taken the most domestic path out of the three daughters. With five kids and a husband who travels overseas for work, Manu is desperate to find something she can call her own. She thrives filling in for her mother as the head of a planned parenthood clinic.